What is SPG Stimulation?

What is SPG Stimulation?

Cluster Headache is one of the most severe and painful headache disorders. Some medicines may help treat an attack or reduce the number of cluster headaches that a person suffers. However, sometimes these medications are not effective or have undesirable side effects.

In these circumstances, a therapy called Sphenopalatine Ganglion (SPG) Stimulation with the Pulsante® Therapy may help.

How It Works


Neurostimulation is a well-established pain treatment used throughout the body to treat chronic pain.Neuromodulation is technology that acts directly upon nerves by altering nerve activity by delivering electrical stimulation directly to the target area.2 As many as 50,000 neurostimulators are implanted worldwide every year.3

Using the same principles, the novel Pulsante SPG Microstimulator is designed to reach the sphenopalatine ganglion (SPG) nerve bundle. The SPG nerve bundle sits behind your cheek. It acts as the body’s “fuse box” along the pain pathway for cluster headaches.  The goal of “stimming” the SPG is to abort or prevent the pain pathways that activate the pain and associated autonomic symptoms of a chronic cluster headache.4

Unlike other therapies, neuromodulation is non-destructive, reversible and adjustable2,3 Once the Pulsante Microstimulator is in place, your clinician can customize the therapy just for you by adjusting features such as intensity of stimulation, duration, and frequency.4


  1. Magis, et al. Neurostimulation therapies for primary headache disorders: present and future. Curr Opin Neurol 2012, 25:269–276
  2. International Neuromodulation Society. What is Neuromodulation? http://www.neuromodulation.com/about-neuromodulation. Access March 2018.
  3. The American Association of Neurological Surgeons. Spinal Cord Stimulation. http://www.aans.org/Patients/Neurosurgical-Conditions-and-Treatments/Spinal-Cord-Stimulation. Accessed March 3, 2018
  4. Tepper, et al. Sphenopalatine Ganglion (SPG): Stimulation Mechanism, Safety, and Efficacy. Headache 2017;57:14-28.